Luminescent marker for determination of orotic acid in drug formulations
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Дата
2021
Назва журналу
Номер ISSN
Назва тому
Видавець
Анотація
Luminescent properties of orotic acid (OA), vitamin B13, a known bioactive
substance, have been studied in this research work. It is shown that inside a
coordination complex of orotic acid with Tb (III) an intermolecular excitation energy
transfer from a ligand to a lanthanide ion happens which causes sensitized
luminescence of Tb (III) ion. Luminescence intensity (Ilum) of Tb (III) increases in the
presence of nonionic and cationic surfactants (SA). It is found that as a result of
attachment of analyte in question onto a solid-phase sorbent with an increase of its
molecular rigidity, more efficient excitation energy transfer is observed followed by
the elevation of luminescence intensity of the coordination complex in the sorbent
solid phase. Luminescence intensity of Tb (III) complex with orotic acid adsorbed
onto the sorbent is estimated by the use of different types of sorbents. The optimum
results are achieved using Silicagel Merck as a solid-phase sorbent. The removal rate
of the complex from the solution in this case reaches to 97%. The optimum
conditions for isolation of orotic acid are specified. On the basis of presented research
work a new analytical procedure technique is developed for the solid-phase
luminescence determination of orotic acid and its salts in medicinal dosage forms.
Опис
Beltyukova S. Luminescent marker for determination of orotic acid in drug formulations / S. Beltyukova, О. Liventsova, О. Teslyuk // The world of science and innovation : proc. of VIII Intern. Sci. and Practical Conf., London (United Kingdom), 10–12 March 2021. – London, 2021. – Р. 35–42 : tabl., fig. – Ref.: 9 tit.
Ключові слова
luminescence, complex, terbium, orotic acid, solid-phase, sorbent